Grafton® DBM vs. Other Bone Graft Substitues

Grafton Demineralized Bone Matrix (DBM) is the surgeon's allograft of choice, with the broadest range of cleared indications among other DBMs or bone graft products.(1) A trusted industry standard, Grafton DBM has been used in more than 800,000 procedures over the past 17 years.

Grafton DBM has been FDA (510k) cleared as a bone graft substitute, bone graft extender, and bone void filler in bony voids or gaps of the skeletal system (i.e. spine, pelvis and extremities) not intrinsic to the stability of the bony structure.

Osteoinductivity


Grafton DBM has the most osteoinductive response of all the DBM product offerings tested, as proven in the athymic rat model, which is the recognized standard for assessing osteoinductivity. (2)

New bone is formed by the active recruitment of stem cells, with the potential to differentiate into bone-forming cells. Of the products tested: Osteofil, Dynagraft II, Allomatrix, DBX, Accell DBM 100, Intergro DBM, and Orthoblast II; Grafton DBM has the most robust osteoinductive response.(2)

Data on File. 04-007A Summary Report Osteoinduction of Competitor Materials in the Athymic Rat. Grafton DBM as compared to the osteoinductivity of Osteofil, Dynagraft II, Allomatrix, DBX, Accell DBM 100, Intergro DBM, and Orthoblast II, when measured in the athymic rat.

Bone Fibers Make the Difference


Osteotech is the exclusive producer of the only commercially available demineralized bone product with patented Bone Fiber Technology.  Bone fibers, instead of bone particles - as is found in competitive DBMs - create a physical network of pathways for bone forming cells to follow.  Studies show that a graft material which provides an osteoconductive scaffold for new bone to build upon aids in the healing process.(3)

Martin, G.J., Boden, S.D., Titus, L., and Scarborough, N.L.: New Formulations of Demineralized Bone Matrix as a More Effective Graft Alternative in Experimental Posterolateral Lumbar Spine Arthodesis. Spine 24 (7):637. 1999.

  • Demineralized Bone Fibers support osteogenesis and osteoconduction
  • Grafton DBM is the only DBM shown to enhance autograft in Non-human Primate Model
  • Osteotech's unique Fiber Technology is also found in the Xpanse® Bone Insert.

> Find out about Grafton DBM's rigorous history of testing