Clinical and Preclinical Studies

Backed by over 15 years of clinical and preclinical sutdies, Grafton® DBM is the obvious choice for most bone grafting procedures.

Clinical and Preclinical Studies

Spine

Fusion Rates After Thoracoscopic Release and Bone Graft Substitutes in Idiopathic Scoliosis
B Weinzapfel, et al. Spine. May 2008 (WP125)

Grafton® & Local Bone Has Comparable Outcomes to Iliac Crest Bone in Single Level Lumbar Fusions
J Kang, et al. November 2007 (WP122)

Rationale for Using Osteotech’s Grafton® DBM Matrix Strips for Spine Deformity and Posterior Cervical Fusions
R Betz, August 2007 (WP109)

Demineralized Bone Matrix Composite Grafting for Posterolateral Spinal Fusion
A Vaccaro, et al. Orthopedics. July 2007 (WP118)

Advances in Osteobiologics in Spine Surgery
S Tim Yoon, MD, PhD. The American Journal of Orthopedics. September 2006. (WP113)

Safety and Efficacy of Demineralized Bone Matrix Used in Posterolateral Lumbar Spine Fusion
B Bose. Neurosurgery Quarterly. March 2006 (WP121)

Two-Year Fusion Rate Equivalency Between Grafton® DBM Gel and Autograft in Posterolateral Spine Fusion
FP Cammisa, et al. SPINE Volume 29, No 6. March 2004. (WP98)

Augmenting Local Bone with Grafton® Demineralized Bone Matrix for Posterolateral Lumbar Spine Fusion: Avoiding Second Site Autologous Bone Harvest
W Sassard, et al. Orthopedics 2000, Vol. 23, No.10. (WP64)

Augmentation of Autologous Bone Grafting with Demineralized Bone Matrix in Posterolateral Lumbar Spinal Fusion
A Castellvi, et al. May 1999 (WP19)

Comparison of Grafting Techniques in Posterolateral Lumbar Spinal Fusions: Long Term Follow-up Results
GL Lowery, et al. Innovation and Technology in Biology and Medicine 16(S1), 1995. (WP30)

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Bone Cysts/Tumors

Treatment of Unicameral Bone Cysts with Percutaneous Injection of Demineralized Bone Matrix and Autogenous Bone Marrow
B Rougraff & T Kling, Journal of Bone & Joint Surgery, June 2002, 84-A No. 6. (WP86)

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Hip & Knee

Core Decompression Augmented with Human Decalcified Bone Matrix Graft for Osteonecrosis of the Femoral Head
RK Aaron, et al. American Academy of Orthopaedic Surgeons, February, 1997. (WP41)

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Foot & Ankle

Augmentation of Hindfoot Arthrodesis with GraftonŽ DBM Putty
A Cantanzariti. 2000 (WP61)

Uses of Grafton for Reconstructive Foot and Ankle Surgery
KE Kado, et al. Journal of Foot and Ankle Surgery, 35(1):59, 1996. (WP46)

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Craniomaxillofacial

Clinical Evaluation of an Allogenic Bone Matrix in the Treatment of Periodontal Osseous Defects
JR Francis, et al. Journal of Periodontology 66: 1074, 1995. (WP72)

Sinus Lift Augmentation to Facilitate Placement of Nonsubmerged Implants
JM Vlassis, et al. Practical Periodontics and Aesthetic Dentistry, 5(2):15, 1993. (WP73)

Performance of GraftonŽ DBM Putty and Flex: Histological Analysis of Implant Sites after Grafting
DP Callen D.D.S (WP53)

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General

Using DBMs in Clinical Orthopedics
T Einhorn, et al. Orthopedics Today, Vol. 25 No. 10, October 2005. (WP108)

Use of Osteopromotive Growth Factors, Demineralized Bone Matrix, and Ceramics to Enhance Spinal Fusion
SN Khan, et al. Journal of the American Academy of Orthopedic Surgeons, 2005; 13; 129-137. (WP105)

Donor Age and Gender Effects on Osteoinductivity of Demineralized Bone Matrix
K Traianedes, et al. Journal of Biomedical Materials Research Part B 70B:21-29, 2004. (WP102)

The Biology of Bone Grafts
VM Goldberg & S Stevenson, Seminars in Arthroplasty, 4(2): 58, 1993. (WP20)

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Safety

The Safety of Glycerol as an Excipient of GraftonŽ Demineralized Bone Matrix (DBM) Grafts
JL Russell, PhD. (WP37)

Allograft Safety: Viral Inactivation with Bone Demineralization
NL Scarborough, et al. Contemporary Orthopaedics, 31(4): 257, 1995. (WP27)

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Long bone

Grafting Long Bone Fractures with Demineralized Bone Matrix Putty Enriched with Bone Marrow: Pilot Findings
R Lindsey, et al. Orthopedics. October 2006 (WP112)

Plate Fixation of Ununited Humeral Shaft Fractures: Effect of Type of Bone Graft on Healing
Hierholzer, Christian MD, et al. Journal of Bone and Joint Surgery. July 2006. Vol 88A No. 7 (WP111)

Grafton DBM Combined with Cancellous Allograft as an Autogenous Graft Substitute in the Treatment of Fractures and Nonunions
FC Redfern (WP94)

Use of Allograft and DBM as an alternative to Pelvic Autograft for the Treatment of Atropic and Oligotrophic Non-Unions
B Ziran, et al. (WP62)

Grafting Long Bone Fractures with a Composite of Demineralized Bone Matrix (DBM) and Autologous Bone Marrow: Results of a Pilot Study
T Moore, et al. (WP34)

Case Report: Treatment of a Comminuted Supracondylar Femur Fracture Using a Femoral Strut Allograft and Demineralized Bone Matrix
FC Redfern (WP31)

Bone Gel-Marrow Aspirate Composite in the Treatment of a Type III B Tibia Fracture: A Case Report
V Leone (WP15)

Treatment of a Femoral Nonunion Using a Bone Graft Gel Composite
JR deAndrade (WP10)

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Pre-Clinical

Evidence of Osteoinduction by GraftonŽ Demineralized Bone Matrix in Nonhuman Primate Spinal Fusion
J Louis-Ugbo, SD Boden, et al. SPINE Volume 29, No 4. February, 2004. (WP97)

Grafton Crunch Heals Critical Sized Segmental Ulna Defects in Rabbit
JM Lane, et al. Hospital for Special Surgery, New York, NY. (WP48)

New Formulations of Demineralized Bone Matrix as a More Effective Graft Alternative in Experimental Posterolateral Lumbar Spine Arthrodesis
GJ Martin, Jr., SD Boden, et al. Spine,1998 24(7):637. (WP42)

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Versus Competition

Interbody Fusion with Allograft and rhBMP-2 Leads to Consistent Fusion But Early Subsidence
R Vaidya, et al. JBJS(BR) March 2007 (WP117)

The Efficacy of Different Commercially Available Demineralized Bone Matrix Substances in an Athymic Rat Model
Yu-Po Lee, MD, et al. Journal of Spinal Disorders & Techniques, October 2005.Vol. 18, No10. (WP107)

Osteoinductivity of Commercially Available Demineralized Bone Matrix: Preparations in a Spine Fusion Model
B Peterson, MD, et al. Journal of Bone & Joint Surgery, October 2004, 86-A No. 10. (WP103)

A Comparative Evaluation of the Osteoinductivity of Two Formulations of Human Demineralized Bone Matrix.
TW Bauer, et al. Orthopaedic Research Society, February, 2001. (WP89)

Comparative Histologic and Calcium Content Evaluation of Osteofil®, Grafton® and Dynagraft® Putty Bone Inductive Materials in the Nude Rat at 28 Days.
WC Fox, et al. North American Spine Society, October 2000. (WP81)

Osteogeneic Activity of OP-1 Bone Morphogenetic Protein (BMP-7) in a Human Fibular Defect
RGT Geesink, et al. Journal of Bone and Joint Surgery (BR)1999, 18-B:710-8. (WP57)

A Histopathologic Comparison of Grafton® DBM Putty and DynaGraft® Putty
T Aufdemorte & TW Bauer. (WP55)

A Comparative Review of the Osteoinductivity of Four Formulations of Allogeneic Demineralized Bone Matrix A Summary of a Blinded, Independent Histopathologic Review of Osteotech Studies
T Aufdemorte & TW Bauer. (WP54)

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